Thinking about plotting the intersections between multiple sets? Stop using venndiagram and try UpSetR. There are lots of powerful things you can do with it. For example, here I am plotting the presence and absence of mutations among multiple tumor samples from different regions of a colorectal tumor. Samples were taken from two broadly defined regions, A and B, within which both bulk and single-gland sampling are available. From the plot shown above, it can be seen that spatial segregation of somatic mutations is evident.